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Ann Neurol. 1987 Oct;22(4):550-2.

Naltrexone decreases self-injurious behavior.

Author information

  • 1Brain Research Center, Children's Hospital National Medical Center, Washington, DC 20010.

Abstract

The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.

PMID:
3481242
[PubMed - indexed for MEDLINE]
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