Ann Neurol. 1987 Oct;22(4):550-2.

Naltrexone decreases self-injurious behavior.

Herman BH, Hammock MK, Arthur-Smith A, Egan J, Chatoor I, Werner A, Zelnik N.

Source

Brain Research Center, Children's Hospital National Medical Center, Washington, DC 20010.

Abstract

The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.

PMID:: 3481242; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Naltrexone

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NALTREXONE - HSDB

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Cited by 1 PubMed Central article

Review Self-injurious behavior in neurodevelopmental disorders: relevance of nociceptive and immune mechanisms. [Neurosci Biobehav Rev. 2011]
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