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J Med Genet. 1987 Nov;24(11):664-8.

Malignant melanoma in families of children with osteosarcoma, chondrosarcoma, and adrenal cortical carcinoma.

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  • 1Department of Epidemiology and Social Oncology, Christie Hospital and Holt Radium Institute, Manchester.

Abstract

Seven cases of malignant melanoma in the close relatives of children with osteosarcoma and chondrosarcoma are described. The association between certain childhood malignancies (adrenal cortical carcinoma, osteosarcoma, chondrosarcoma, retinoblastoma) and malignant melanoma is discussed and it is proposed that in certain families malignant melanoma may be another manifestation of the same gene defect which results in susceptibility to tumours characteristic of the SBLA cancer family syndrome.

PMID:
3480957
PMCID:
PMC1050343
[PubMed - indexed for MEDLINE]
Free PMC Article
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