Molecular mechanisms underlying the effect of diacerein on trichloroacetic acid-induced hepatic pre-neoplastic lesions in rats

Hum Exp Toxicol. 2021 Dec;40(12_suppl):S788-S803. doi: 10.1177/09603271211056331. Epub 2021 Nov 18.

Authors

Yasmine F Ibrahim¹, Marwa Mm Refaie¹, Maha Y Kamel¹, Sara M Ahmed¹, Rabab A Moussa², Asmaa Ma Bayoumi^{3

4}, Mohamed A Ibrahim¹

Affiliations

¹ Department of Pharmacology, Faculty of Medicine, 68877Minia University, Minia, Egypt.
² Department of Pathology, Faculty of Medicine, 68877Minia University, Minia, Egypt.
³ Department of Biochemistry, Faculty of Pharmacy, 68877Minia University, Minia, Egypt.
⁴ Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

PMID: 34794354
DOI: 10.1177/09603271211056331

Abstract

IL-1β mediates angiogenesis indirectly, as it has been shown to induce hypoxia-inducible factor-1α (HIF-1α) which upregulates VEGF.

Keywords: caspase-3; diacerein; hypoxia-inducible factor-1α; trichloroacetic acid; vascular endothelial growth factor.

MeSH terms

Animals
Anthraquinones / toxicity*
Liver Neoplasms, Experimental / chemically induced*
Precancerous Conditions / chemically induced*
Rats
Trichloroacetic Acid / toxicity*

Substances

Anthraquinones
diacerein
Trichloroacetic Acid