Proc Natl Acad Sci U S A. 1987 Oct;84(20):7218-20.

High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosis.

Soriano P, Keitges EA, Schorderet DF, Harbers K, Gartler SM, Jaenisch R.

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Whitehead Institute for Biomedical Research, Cambridge, MA 02142.

Abstract

The recombination rate in meiosis between the mouse X and Y chromosomes was analyzed. Mice heterozygous at two pseudoautosomal alleles, the steroid sulfatase gene and the Mov-15 provirus marker, were crossed. The provirus in the Mov-15 transgenic mouse strain had been previously shown to be carried in the pseudoautosomal region of the sex chromosomes. Recombination frequencies were shown to be 7-fold higher in this region in male meiosis than in female meiosis. Three-point crosses indicated the occurrence in male meiosis of double recombination events in the pseudoautosomal region, with little or no crossover interference, which is in marked contrast to observations made on the similar region of the human sex chromosomes. This result is contrary to a previous model, which predicted a single crossover event in male meiotic pairing of mammalian sex chromosomes.

PMID:: 3478692; [PubMed - indexed for MEDLINE]
PMCID:: PMC299261

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Linkage of the murine steroid sulfatase locus, Sts, to sex reversed, Sxr: a genetic and molecular analysis. [Nucleic Acids Res. 1987]
Linkage of the murine steroid sulfatase locus, Sts, to sex reversed, Sxr: a genetic and molecular analysis.
Nagamine CM, Michot JL, Roberts C, Guénet JL, Bishop CE. Nucleic Acids Res. 1987 Nov 25; 15(22):9227-38.
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Review The mammalian pseudoautosomal region.
Ellis N, Goodfellow PN. Trends Genet. 1989 Dec; 5(12):406-10.
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Review Sex-chromosome pairing and activity during mammalian meiosis.
Handel MA, Hunt PA. Bioessays. 1992 Dec; 14(12):817-22.

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Cited by 11 PubMed Central articles

Distinct properties of the XY pseudoautosomal region crucial for male meiosis. [Science. 2011]
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High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosis.

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