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Science. 1978 May 5;200(4341):567-8.

Schizophrenic symptoms improve with apomorphine.

Abstract

Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

PMID:
347574
[PubMed - indexed for MEDLINE]
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