Pancreatic beta cell neogenesis: Debates and updates

Huan Zhao; Kathy O Lui; Bin Zhou

doi:10.1016/j.cmet.2021.10.007

Pancreatic beta cell neogenesis: Debates and updates

Cell Metab. 2021 Nov 2;33(11):2105-2107. doi: 10.1016/j.cmet.2021.10.007.

Authors

Huan Zhao¹, Kathy O Lui², Bin Zhou³

Affiliations

¹ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
² Department of Chemical Pathology and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
³ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address: zhoubin@sibs.ac.cn.

PMID: 34731654
DOI: 10.1016/j.cmet.2021.10.007

Abstract

Finding endogenous, renewable sources for insulin-producing beta cells in the adult pancreas is one of the holy grails of stem cell research and regenerative medicine. Through lineage tracing and scRNA-seq approaches, Gribben et al. (2021) have recently reported that Ngn3-expressing ductal cells could serve as progenitors for new beta cells in the adult pancreas.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Insulin-Secreting Cells*
Pancreas