Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

Xiaojuan Li; Tiewei Li; Jingjing Wang; Yichuan Feng; Chong Ren; Zhe Xu; Junmei Yang; Qian Zhang; Caiyan An

doi:10.2147/JIR.S334642

Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

J Inflamm Res. 2021 Oct 6:14:5123-5129. doi: 10.2147/JIR.S334642. eCollection 2021.

Authors

Xiaojuan Li¹, Tiewei Li¹, Jingjing Wang², Yichuan Feng¹, Chong Ren¹, Zhe Xu¹, Junmei Yang¹, Qian Zhang³, Caiyan An⁴

Affiliations

¹ Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, People's Republic of China.
² Department of Neonatology, Ordos Central Hospital, Ordos, 01700, People's Republic of China.
³ The Center for New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot, People's Republic of China.
⁴ Clinical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, People's Republic of China.

Abstract

Purpose: C-reactive protein (CRP) level and platelet (PLT) count have been demonstrated to be independent risk factor for neonatal sepsis. However, no data is currently available in regarding the association between CRP-to-PLT ratio (CPR) and neonatal sepsis.

Methods: A total of 1048 neonates with suspected sepsis were enrolled in this study. Complete clinical and laboratory data were collected. CPR was calculated as CRP (mg/L)/PLT (10⁷ cells/L). Multivariate logistic regression analysis was performed to identify the potential independent risk factors of neonatal sepsis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CPR in predicting neonatal sepsis.

Results: Neonates with sepsis had a higher CPR. CPR also showed a gradual increase in the infection, mild sepsis and severe sepsis groups. Multivariate analysis revealed that CPR was a significant independent predictor of the presence of neonatal sepsis (odds ratio [OR], 1.015; 95% confidence interval [CI], 1.008-1.022, P < 0.001) and severe sepsis (OR, 1.002; 95% CI, 1.000-1.003, P = 0.007). ROC curve revealed showed that CPR had a well-discriminatory power in predicting sepsis (area under curve [AUC], 0.68; 95% CI, 0.65-0.72, P < 0.001) and severe sepsis (AUC, 0.68; 95% CI, 0.65-0.72, P < 0.001).

Conclusion: The present study demonstrated that a higher CPR is an independent predictor of the presence and severity of neonatal sepsis.

Keywords: C-reactive protein-to-platelet ratio; neonatal sepsis; risk factor; severe sepsis.

Grants and funding

This study was funded by the Key Research, Development, and Promotion Projects of Henan Province (202102310132), and the Medical Science and Technology Project of Henan Province (LHGJ20190970, LHGJ20200642 and LHGJ20200651).