A Novel Function of Sphingolipid Signaling via S1PR3 in Hematopoietic and Leukemic Stem Cells

Chong Yang; Masayuki Yamashita; Toshio Suda

doi:10.1158/2643-3230.BCD-20-0200

A Novel Function of Sphingolipid Signaling via S1PR3 in Hematopoietic and Leukemic Stem Cells

Blood Cancer Discov. 2020 Dec 1;2(1):3-5. doi: 10.1158/2643-3230.BCD-20-0200. eCollection 2021 Jan.

Authors

Chong Yang¹, Masayuki Yamashita², Toshio Suda^{1

3}

Affiliations

¹ Cancer Science Institute of Singapore, National University of Singapore, Singapore.
² Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Bunkyo, Tokyo, Japan.
³ International Research Center for Medical Sciences, Kumamoto University, Chuo Ward, Kumamoto, Japan.

Abstract

In this issue of Blood Cancer Discovery, Xie and colleagues describe a novel function of sphingosine-1-phosphate receptor 3 (S1PR3) to regulate myeloid differentiation and activate inflammatory programs in both human hematopoietic stem cells and leukemic stem cells. They propose S1PR3 as a major downstream signaling pathway of a TNFα-NF-κB axis in this study and unlock potential therapeutic opportunities to improve outcomes of patients with acute myeloid leukemia by modulating sphingolipid signaling via S1PR3. See related article by Xie et al., p. 32.

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