A Chinese Child Presented with Early T Cell Precursor Lymphoblastic Lymphoma

Xiangyang Pu; Shengyong Deng; Nange Yin; Lin Song; Xiangling He; Jianwen Xiao

doi:10.1155/2021/5561860

A Chinese Child Presented with Early T Cell Precursor Lymphoblastic Lymphoma

Case Rep Hematol. 2021 Sep 28:2021:5561860. doi: 10.1155/2021/5561860. eCollection 2021.

Authors

Xiangyang Pu^{1

2}, Shengyong Deng^{1

2}, Nange Yin^{1

3}, Lin Song^{3

4

5}, Xiangling He⁶, Jianwen Xiao^{1

7

8}

Affiliations

¹ Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.
² Department of Pediatric Respiratory Medicine, Qianjiang Central Hospital of Chongqing, Chongqing, China.
³ Department of Pharmacy, Children Hospital of Chongqing Medical University, Chongqing, China.
⁴ National Clinical Research Center for Child Health and Disorders, Chongqing, China.
⁵ China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
⁶ Department of Pediatric Hematology and Oncology, Children's Medical Center of Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Changsha, China.
⁷ Chongqing Key Laboratory of Pediatrics, Chongqing, China.
⁸ Department of Hematology, Children Hospital of Chongqing Medical University, Chongqing, China.

Abstract

T cell lymphoblastic lymphoma (T-LBL) is regarded as the leukemic phase of T cell acute lymphoblastic leukemia (T-ALL). The early T cell precursors ALL/LBL (ETP-LBL/ALL) are derived from thymic cells at the ETP differentiation stage and recognized as a high-risk subgroup of T-ALL/LBL. Most of these cases presented with ALL at the disease onset, but the ETP-LBL phase is uncommon. Here, we report a patient who presented with ETP-LBL at the disease onset. In this case, ALL developed even despite receiving chemotherapy, but the patient achieved a complete remission with intensive chemotherapy.

Publication types

Case Reports