Nature. 1986 Mar 6-12;320(6057):84-5.

Localization of gene for human p53 tumour antigen to band 17p13.

Isobe M, Emanuel BS, Givol D, Oren M, Croce CM.

Abstract

Recently the gene for the cellular tumour antigen p53, a phosphoprotein found in increased concentration in a variety of human cells, had been mapped to region 17q22 by in situ hybridization techniques and has been shown to translocate to the chromosome carrying the translocation [t(15; 17)] associated with acute promyelocytic leukaemia (APL). Based on this finding it has been postulated that this gene has a role in the pathogenesis of APL. Here we present evidence that the gene for p53 is not located on the long arm of chromosome 17, but maps to band 17p13. We therefore suggest that this gene is not directly involved in the chromosome translocation observed in APL.

PMID:: 3456488; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Antigens, Neoplasm

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Acute Myeloid Leukemia - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia. [Nature. 1985]
Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia.
Le Beau MM, Westbrook CA, Diaz MO, Rowley JD, Oren M. Nature. 1985 Aug 29-Sep 4; 316(6031):826-8.
The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13). [Proc Natl Acad Sci U S A. 1986]
The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).
McBride OW, Merry D, Givol D. Proc Natl Acad Sci U S A. 1986 Jan; 83(1):130-4.
Localization of myeloperoxidase to the long arm of human chromosome 17: relationship to the 15; 17 translocation of acute promyelocytic leukemia. [Oncogene. 1987]
Localization of myeloperoxidase to the long arm of human chromosome 17: relationship to the 15; 17 translocation of acute promyelocytic leukemia.
van Tuinen P, Johnson KR, Ledbetter SA, Nussbaum RL, Rovera G, Ledbetter DH. Oncogene. 1987; 1(3):319-22.
Review The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias. [Haematologica. 1997]
Review The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias.
Lo Coco F, Pisegna S, Diverio D. Haematologica. 1997 May-Jun; 82(3):364-70.
Review PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia. [Haematologica. 1996]
Review PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia.
Pandolfi PP. Haematologica. 1996 Sep-Oct; 81(5):472-82.

See reviews... See all...

Cited by 44 PubMed Central articles

PEDF - A Noninhibitory Serpin with Neurotrophic Activity. [Acta Naturae. 2010]
PEDF - A Noninhibitory Serpin with Neurotrophic Activity.
Minkevich NI, Lipkin VM, Kostanyan IA. Acta Naturae. 2010 Jul; 2(3):62-71.
Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells. [Int J Nanomedicine. 2011]
Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells.
Karmakar A, Bratton SM, Dervishi E, Ghosh A, Mahmood M, Xu Y, Saeed LM, Mustafa T, Casciano D, Radominska-Pandya A, et al. Int J Nanomedicine. 2011; 6:1045-55. Epub 2011 May 18.
Purification of lectin from larvae of the fly, Musca domestica, and in vitro anti-tumor activity in MCF-7 cells. [J Insect Sci. 2010]
Purification of lectin from larvae of the fly, Musca domestica, and in vitro anti-tumor activity in MCF-7 cells.
Cao X, Huo Z, Lu M, Mao D, Zhao Q, Xu C, Wang C, Zeng B. J Insect Sci. 2010; 10:164.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Localization of gene for human p53 tumour antigen to band 17p13.
Localization of gene for human p53 tumour antigen to band 17p13.
Nature. 1986 Mar 6-12 ;320(6057):84-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: