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Localization of the human haptoglobin genes distal to the fragile site at 16q22 using in situ hybridization.
The distamycin A-sensitive fragile site fra(16)(q22) is a precisely localized chromosomal marker. When expressed at metaphase, it visibly separates the chromosome material on either side of the fragile site. Using a cDNA probe encoding both the alpha and beta haptoglobin chains, the haptoglobin loci were found by in situ hybridization to be distal to fra(16)(q22).
PMID: 3455911 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Mapping the human alpha globin gene complex to 16p13.2----pter.
Simmers RN, Mulley JC, Hyland VJ, Callen DF, Sutherland GR.
J Med Genet. 1987 Dec; 24(12):761-6.
[J Med Genet. 1987]
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Anonymous DNA probes to human chromosome 16 derived from a flow-purified library.
Hyland VJ, Grist S, Callen DF, Sutherland GR.
Am J Hum Genet. 1988 Feb; 42(2):373-9.
[Am J Hum Genet. 1988]
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A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection.
Durnam DM, Menninger JC, Chandler SH, Smith PP, McDougall JK.
Mol Cell Biol. 1988 May; 8(5):1863-7.
[Mol Cell Biol. 1988]
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