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Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.
The primary structure of human uromodulin, a 616-amino acid, 85-kilodalton glycoprotein with in vitro immunosuppressive properties, was determined through isolation and characterization of complementary DNA and genomic clones. The amino acid sequence encoded by one of the exons of the uromodulin gene has homology to the low-density-lipoprotein receptor and the epidermal growth factor precursor. Northern hybridization analyses demonstrate that uromodulin is synthesized by the kidney. Evidence is provided that uromodulin is identical to the previously characterized Tamm-Horsfall glycoprotein, the most abundant protein in normal human urine.
PMID: 3453112 [PubMed - indexed for MEDLINE]
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Cited by 20 PubMed Central articles
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Goat uromodulin promoter directs kidney-specific expression of GFP gene in transgenic mice.
Huang YJ, Chretien N, Bilodeau AS, Zhou JF, Lazaris A, Karatzas CN.
BMC Biotechnol. 2005 Apr 11; 5:9. Epub 2005 Apr 11.
[BMC Biotechnol. 2005]
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Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy.
Hart TC, Gorry MC, Hart PS, Woodard AS, Shihabi Z, Sandhu J, Shirts B, Xu L, Zhu H, Barmada MM, et al.
J Med Genet. 2002 Dec; 39(12):882-92.
[J Med Genet. 2002]
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Uromodulin promoter directs high-level expression of biologically active human alpha1-antitrypsin into mouse urine.
Zbikowska HM, Soukhareva N, Behnam R, Lubon H, Hammond D, Soukharev S.
Biochem J. 2002 Jul 1; 365(Pt 1):7-11.
[Biochem J. 2002]
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