Graphene-Assisted Electrochemical Sensor for Detection of Pancreatic Cancer Markers

Front Chem. 2021 Aug 19:9:733371. doi: 10.3389/fchem.2021.733371. eCollection 2021.

Abstract

Pancreatic cancer is a highly lethal gastrointestinal malignancy. Most patients are already in the middle to advanced stages of pancreatic cancer at the time of diagnosis and cannot be treated completely. As a single-atom planar two-dimensional crystal, graphene's unusual electronic structure, specific electronic properties and excellent electron transport capacity make it uniquely advantageous in the field of electrochemical sensing. In this mini-review, we summarize the potential application of graphene in pancreatic cancer detection. K-Ras gene, CEA and MicroRNA are important in the early diagnosis of pancreatic cancer.

Keywords: CEA; k-ras gene; microRNA-196a; microRNA-21; pancreatic cancer; signal amplification.

Publication types

  • Review