Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

John Hansen; Michael D Decker; Edwin Lewis; Bruce Fireman; Vitali Pool; David P Greenberg; David R Johnson; Steven Black; Nicola P Klein

doi:10.1097/INF.0000000000003308

Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

Pediatr Infect Dis J. 2021 Dec 1;40(12):1122-1126. doi: 10.1097/INF.0000000000003308.

Authors

John Hansen¹, Michael D Decker², Edwin Lewis¹, Bruce Fireman¹, Vitali Pool², David P Greenberg², David R Johnson², Steven Black³, Nicola P Klein¹

Affiliations

¹ From the Kaiser Permanente Vaccine Study Center, Oakland, California.
² Sanofi Pasteur, Swiftwater, Pennsylvania.
³ Cincinnati Children's Hospital, Cincinnati, Ohio.

Abstract

Background: Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines.

Methods: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine.

Results: We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8-39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children.

Conclusions: These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adverse Drug Reaction Reporting Systems
Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects*
Female
Humans
Infant
Male
Muscle Hypotonia / etiology*
Vaccination / adverse effects*

Substances

Diphtheria-Tetanus-acellular Pertussis Vaccines