Microbes as a production host to produce natural activecompounds from mushrooms: biosynthetic pathway elucidationand metabolic engineering

Chin J Nat Med. 2021 Aug;19(8):580-590. doi: 10.1016/S1875-5364(21)60058-4.

Abstract

Mushrooms are abundant in bioactive natural compounds. Due to strict growth conditions and long fermentation-time, microbe as a production host is an alternative and sustainable approach for the production of natural compounds. This review focuses on the biosynthetic pathways of mushroom originated natural compounds and microbes as the production host for the production of the above natural compounds.

Keywords: Metabolic engineering; Microbes; Mushroom; Natural compound; Synthetic biology.

Publication types

  • Review

MeSH terms

  • Agaricales* / chemistry
  • Bacteria / metabolism*
  • Biological Products / metabolism*
  • Biosynthetic Pathways*
  • Fermentation
  • Metabolic Engineering*

Substances

  • Biological Products