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    Psychol Med. 1987 Nov;17(4):899-904.

    Mood swings associated with the 'on-off' phenomenon in Parkinson's disease.

    Nissenbaum H, Quinn NP, Brown RG, Toone B, Gotham AM, Marsden CD.

    Source

    University Department of Psychological Medicine, Kings College School of Medicine and Dentistry, London.

    Abstract

    Mood swings accompanying the motor fluctuations of patients with Parkinson's disease on chronic levodopa treatment frequently occur, but are poorly recognized. Occasionally, their functional impact may be greater than that caused by the motor disability itself. In this study we have assessed the nature of, and relationship between, mood and motor fluctuations in nine Parkinsonian patients with 'on-off' motor swings. The results of an additional questionnaire survey confirm that 'on-off' mood swings occur in approximately two thirds of patients with Parkinson's disease experiencing motor fluctuations on dopaminergic treatment. Aetiological and therapeutic implications are discussed.

    PMID:
    3432464
    [PubMed - indexed for MEDLINE]

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