Acta Paediatr Scand. 1987 Nov;76(6):955-61.

Management of Pseudomonas aeruginosa lung infection in Danish cystic fibrosis patients.

Pedersen SS, Jensen T, Høiby N, Koch C, Flensborg EW.

Source

Department of Paediatrics, Rigshospitalet, Copenhagen, Denmark.

Abstract

The annual mortality rate of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection at the Danish CF-centre ranged from 10 to 20% in the years 1970-1975. In this period the patients received antipseudomonal chemotherapy only during acute exacerbations of infection. From 1976 99 patients acquired chronic P. aeruginosa infection and were given regular and intensive antipseudomonal treatment 3-4 times per year. The patients were followed for 612 patient-years; 7 died and the 10-year survival rate after onset of P. aeruginosa infection was 90% +/- 4%. The annual mortality rate is now 1-2%. Although precipitating antibodies against P. aeruginosa increased significantly, pulmonary function did not deteriorate with duration of infection. Cross-infection between patients caused an increased incidence of chronic P. aeruginosa infection which was reduced by hygienic measures.

PMID:: 3425313; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Molecular Biology Databases

TOBRAMYCIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Frequent antibiotic therapy improves survival of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection. [Acta Paediatr Scand. 1983]
Frequent antibiotic therapy improves survival of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection.
Szaff M, Høiby N, Flensborg EW. Acta Paediatr Scand. 1983 Sep; 72(5):651-7.
Review The treatment of respiratory pseudomonas infection in cystic fibrosis: what drug and which way? [Drugs. 2000]
Review The treatment of respiratory pseudomonas infection in cystic fibrosis: what drug and which way?
Banerjee D, Stableforth D. Drugs. 2000 Nov; 60(5):1053-64.
A formulation of aerosolized tobramycin (Bramitob) in the treatment of patients with cystic fibrosis and Pseudomonas aeruginosa infection: a double-blind, placebo-controlled, multicenter study. [Paediatr Drugs. 2007]
A formulation of aerosolized tobramycin (Bramitob) in the treatment of patients with cystic fibrosis and Pseudomonas aeruginosa infection: a double-blind, placebo-controlled, multicenter study.
Chuchalin A, Csiszér E, Gyurkovics K, Bartnicka MT, Sands D, Kapranov N, Varoli G, Monici Preti PA, Mazurek H. Paediatr Drugs. 2007; 9 Suppl 1:21-31.
Review Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis. [Drugs. 2003]
Review Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis.
Cheer SM, Waugh J, Noble S. Drugs. 2003; 63(22):2501-20.
Antibody response to Pseudomonas aeruginosa in cystic fibrosis patients: a marker of therapeutic success?--A 30-year cohort study of survival in Danish CF patients after onset of chronic P. aeruginosa lung infection. [Pediatr Pulmonol. 2004]
Antibody response to Pseudomonas aeruginosa in cystic fibrosis patients: a marker of therapeutic success?--A 30-year cohort study of survival in Danish CF patients after onset of chronic P. aeruginosa lung infection.
Johansen HK, Nørregaard L, Gøtzsche PC, Pressler T, Koch C, Høiby N. Pediatr Pulmonol. 2004 May; 37(5):427-32.

See reviews... See all...

Cited by 12 PubMed Central articles

Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms. [Antimicrob Agents Chemother. 2...]
Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.
Bagge N, Hentzer M, Andersen JB, Ciofu O, Givskov M, Høiby N. Antimicrob Agents Chemother. 2004 Apr; 48(4):1168-74.
Review Infection control in cystic fibrosis. [Clin Microbiol Rev. 2004]
Review Infection control in cystic fibrosis.
Saiman L, Siegel J. Clin Microbiol Rev. 2004 Jan; 17(1):57-71.
Long-term survival and nutritional data in patients with cystic fibrosis treated in a Danish centre. [Thorax. 1996]
Long-term survival and nutritional data in patients with cystic fibrosis treated in a Danish centre.
Nir M, Lanng S, Johansen HK, Koch C. Thorax. 1996 Oct; 51(10):1023-7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Management of Pseudomonas aeruginosa lung infection in Danish cystic fibrosis pa...
Management of Pseudomonas aeruginosa lung infection in Danish cystic fibrosis patients.
Acta Paediatr Scand. 1987 Nov ;76(6):955-61.

PubMed
The clinical use of combined xenografts of bone and autologous red marrow. A pre...
The clinical use of combined xenografts of bone and autologous red marrow. A preliminary report.
J Bone Joint Surg Br. 1978 Feb ;60(1):111-5.

PubMed
Intra- and inter-observer variability in the assessment of intrapartum cardiotoc...
Intra- and inter-observer variability in the assessment of intrapartum cardiotocograms.
Acta Obstet Gynecol Scand. 1987 ;66(5):421-4.

PubMed
[Effectiveness of the therapeutic use of complexones in various diseases of the ...
[Effectiveness of the therapeutic use of complexones in various diseases of the extrapyramidal system in children].
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987 ;87(10):1457-62.

PubMed
Transport-defective Escherichia coli ecf mutant permeable to protons and nucleot...
Transport-defective Escherichia coli ecf mutant permeable to protons and nucleotides.
J Bacteriol. 1978 Feb ;133(2):1008-14.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Management of Pseudomonas aeruginosa lung infection in Danish cystic fibrosis patients.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 12 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information