[Application of Mdr2 gene knockout mice in liver disease research]

Zhonghua Gan Zang Bing Za Zhi. 2021 Jun 20;29(6):585-590. doi: 10.3760/cma.j.cn501113-20191007-00364.
[Article in Chinese]

Abstract

Mdr2 knockout mice is a liver disease model, which causes cholestasis due to the lack of phospholipids in the bile. At present, it is not only used for the study of human homologous MDR3 gene, but also widely used as an animal model of liver diseases such as primary sclerosing cholangitis, liver fibrosis, progressive familial intrahepatic cholestasis, liver cancer. Herein, we review the Mdr2 knockout mice physiological characteristics and its application in liver disease research.

Mdr2基因敲除小鼠是因胆汁中磷脂缺乏而导致胆汁淤积的一种肝病模型。目前不仅用于其人类同源基因MDR3的研究,同时还作为原发性硬化性胆管炎、肝纤维化、进行性家族性肝内胆汁瘀积症、肝癌等多种肝病的动物模型而被广泛使用。在此我们对Mdr2基因敲除小鼠的生理特点及在肝病研究中的应用作一综述。.

Keywords: Animal model; Hepatic fibrosis; Liver cancer; Primary sclerosing cholangitis.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / genetics
  • Animals
  • Cholangitis, Sclerosing* / genetics
  • Cholestasis, Intrahepatic*
  • Disease Models, Animal
  • Gene Knockout Techniques
  • Liver
  • Mice
  • Mice, Knockout

Substances

  • ATP Binding Cassette Transporter, Subfamily B