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Hum Genet. 1988 Feb;78(2):148-50.

Loss of der(3) in renal carcinoma cells of a patient with constitutional t(3;12).

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  • 1Cytogenetisches Labor, Institut für Pathologie, Hannover, Federal Republic of Germany.


Cytogenetic studies were performed on peripheral lymphocytes, normal kidney cells, and tumor cells of a patient with renal cell carcinoma. Chromosome analysis of normal somatic cells revealed a constitutional t(3;12)(q13.2;q24.1) and a genomic instability involving the derivative chromosome 12. On the other hand, tumor cells were characterized by loss of der(3), supporting the hypothesis that loss of a specific 3p segment is associated with the development of renal cancer.

[PubMed - indexed for MEDLINE]
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