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Science. 1979 Mar 16;203(4385):1111-2.

Phosphorylation of Isocitrate dehydrogenase of Escherichia coli.

Abstract

Addition of acetate to a stationary phase culture of Escherichia coli in glycerol mineral salts medium containing phosphorus-32-labeled orthophosphate results in rapid loss of isocitrate dehydrogenase activity and concomitant incorporation of phosphorus-32 into the enzyme. This is the first example of protein phosphorylation in a bacterium in which the endogenous substrate for the protein kinase has been identified.

PMID:
34215
[PubMed - indexed for MEDLINE]
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