Science. 1988 Sep 16;241(4872):1503-6.

Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3.

Holm C, Kirchgessner TG, Svenson KL, Fredrikson G, Nilsson S, Miller CG, Shively JE, Heinzmann C, Sparkes RS, Mohandas T, et al.

Source

Department of Medical and Physiological Chemistry, University of Lund, Sweden.

Abstract

Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin. The 757-amino acid sequence predicted from a cloned rat adipocyte complementary DNA showed no homology with any other known lipase or protein. The activity-controlling phosphorylation site was localized to Ser563 in a markedly hydrophilic domain, and a lipid-binding consensus site was tentatively identified. One or several messenger RNA species (3.3, 3.5, or 3.9 kilobases) were expressed in adipose and steroidogenic tissues and heart and skeletal muscle. The human hormone-sensitive lipase gene mapped to chromosome 19 cent-q13.3.

PMID:: 3420405; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

PhosphoSitePlus® - comprehensive post-translational modification resource - PhosphoSitePlus

Research Materials

Coriell Cell Repositories

Supplemental Content

Save items

Related citations in PubMed

The hormone-sensitive lipase (LIPE) gene located on chromosome 19q13.1-->13.2 is not duplicated on 19p13.3. [Int J Obes Relat Metab Disord....]
The hormone-sensitive lipase (LIPE) gene located on chromosome 19q13.1-->13.2 is not duplicated on 19p13.3.
Laurell H, Grober J, Holst LS, Holm C, Mohrenweiser HW, Langin D. Int J Obes Relat Metab Disord. 1995 Aug; 19(8):590-2.
Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->q13.2. [Cytogenet Cell Genet. 1995]
Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->q13.2.
Levitt RC, Liu Z, Nouri N, Meyers DA, Brandriff B, Mohrenweiser HM. Cytogenet Cell Genet. 1995; 69(3-4):211-4.
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. [Genomics. 1996]
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.
Holst LS, Langin D, Mulder H, Laurell H, Grober J, Bergh A, Mohrenweiser HW, Edgren G, Holm C. Genomics. 1996 Aug 1; 35(3):441-7.
Review Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. [Annu Rev Nutr. 2000]
Review Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
Holm C, Osterlund T, Laurell H, Contreras JA. Annu Rev Nutr. 2000; 20:365-93.
Review Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. [Biochem Soc Trans. 2003]
Review Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
Holm C. Biochem Soc Trans. 2003 Dec; 31(Pt 6):1120-4.

See reviews... See all...

Cited by 32 PubMed Central articles

Review The metabolic serine hydrolases and their functions in mammalian physiology and disease. [Chem Rev. 2011]
Review The metabolic serine hydrolases and their functions in mammalian physiology and disease.
Long JZ, Cravatt BF. Chem Rev. 2011 Oct 12; 111(10):6022-63. Epub 2011 Jun 23.
Review Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling. [Chem Rev. 2011]
Review Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling.
Coleman RA, Mashek DG. Chem Rev. 2011 Oct 12; 111(10):6359-86. Epub 2011 Jun 1.
A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN Study) on chromosome 19q12-13. [Obesity (Silver Spring). 2011]
A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN Study) on chromosome 19q12-13.
Voruganti VS, Diego VP, Haack K, Cole SA, Blangero J, Göring HH, Laston S, Wenger CR, Ebbesson SO, Fabsitz RR, et al. Obesity (Silver Spring). 2011 Sep; 19(9):1840-6. Epub 2011 Apr 28.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSample
BioSample links
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Hormone-sensitive lipase: sequence, expression, and chromosomal localization to ...
Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3.
Science. 1988 Sep 16 ;241(4872):1503-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: