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1: Nature. 1988 Sep 29;335(6189):448-51.Click here to read Links

Structure and function of human perforin.

Lichtenheld MG, Olsen KJ, Lu P, Lowrey DM, Hameed A, Hengartner H, Podack ER.

Department of Microbiology and Immunology, University of Miami, School of Medicine, Florida 33101.

Perforin (P1) is a cytolytic protein with similarity to complement component C9. P1 has been described as a unique component of murine cytolytic T-cell and rat natural killer cell granules Previous studies indicated that human granules and P1 differed from murine granules and P1 in that they appeared to be cytolytically less active and lacked the haemolytic activity characteristic of P1. It has been suggested that P1, like C9, is under the control of the homologous restriction factor. Here we determine the primary structure of human P1, re-examine its functional properties, and address the question of homologous restriction.

PMID: 3419519 [PubMed - indexed for MEDLINE]