Iatrogenic disease is considered as an unintentional or occasionally inevitable damage to the patient which is caused by the medical personnel during the patient management or at examinations, diagnostic and therapeutic procedures. Iatrogenesis, being the reverse side of medicine, is an essential part of medical progress. Any therapeutic exposures, especially to invasive techniques, are prone to both positive and negative effects. The development of the physician's skill, cultural standard, refinement, continuing self-education and analysis of errors in line with governmental program to improve public health are to warrant iatrogenic disease control.