Am J Clin Nutr. 1988 Sep;48(3):601-4.

Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract.

Source

Department of Chemistry, University of Scranton, PA 18510.

Abstract

This study was performed to determine whether synthetic ascorbic acid (AA) alone or in a natural citrus extract containing bioflavonoids, proteins, and carbohydrates was more bioavailable to human subjects. The effect of a single 500-mg ascorbate dose of the two forms and a placebo citrus extract on plasma ascorbate was examined in eight fasting subjects. A comparison of the areas under the plasma concentration-time curves showed that the citrus extract was 35% more absorbed than AA (p less than 0.001) and was more slowly absorbed than AA (p less than 0.001). In six ascorbate-saturated male subjects the ascorbate in the citrus extract produced a greater ascorbate excretion than AA alone in 24-h post-dose urine (p less than 0.05). Citrus extract ascorbate was less excreted than AA (p less than 0.05) in 12 nonsaturated subjects. Ascorbate in the citrus extract was found to be more bioavailable than AA alone in human subjects.

PMID:: 3414575; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Vitamin C - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. [Phytomedicine. 2005]
Effect of Aloe vera preparations on the human bioavailability of vitamins C and E.
Vinson JA, Al Kharrat H, Andreoli L. Phytomedicine. 2005 Nov; 12(10):760-5.
The use of a nonlinear absorption model in the study of ascorbic acid bioavailability in man. [Biopharm Drug Dispos. 1993]
The use of a nonlinear absorption model in the study of ascorbic acid bioavailability in man.
Piotrovskij VK, Kállay Z, Gajdos M, Geryková M, Trnovec T. Biopharm Drug Dispos. 1993 Jul; 14(5):429-42.
Review Vitamin C and the role of citrus juices as functional food. [Nat Prod Commun. 2009]
Review Vitamin C and the role of citrus juices as functional food.
Martí N, Mena P, Cánovas JA, Micol V, Saura D. Nat Prod Commun. 2009 May; 4(5):677-700.
Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects. [Br J Nutr. 2004]
Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects.
Bates CJ, Jones KS, Bluck LJ. Br J Nutr. 2004 May; 91(5):699-705.
Review Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics. [Int J Toxicol. 2005]
Review Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics.
Elmore AR. Int J Toxicol. 2005; 24 Suppl 2:51-111.

See reviews... See all...

Cited by 1 PubMed Central article

Bioavailability and antioxidant effects of orange juice components in humans. [J Agric Food Chem. 2005]
Bioavailability and antioxidant effects of orange juice components in humans.
Franke AA, Cooney RV, Henning SM, Custer LJ. J Agric Food Chem. 2005 Jun 29; 53(13):5170-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Comparative bioavailability to humans of ascorbic acid alone or in a citrus extr...
Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract.
Am J Clin Nutr. 1988 Sep ;48(3):601-4.

PubMed
Participation of Hageman factor dependent pathways in human disease states.
Participation of Hageman factor dependent pathways in human disease states.
Thromb Haemost. 1977 Dec 15 ;38(4):751-75.

PubMed
The "neuroleptic" antipsychotic drugs. 1. Mechanisms of action.
The "neuroleptic" antipsychotic drugs. 1. Mechanisms of action.
Postgrad Med. 1979 Apr ;65(4):108-11, 114-9.

PubMed
Responses of simple and complex cells to compound sine-wave gratings.
Responses of simple and complex cells to compound sine-wave gratings.
Vision Res. 1988 ;28(1):25-39.

PubMed
Assignment of the structural genes for the alpha subunit of hexosaminidase A, ma...
Assignment of the structural genes for the alpha subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15.
Somatic Cell Genet. 1977 Nov ;3(6):553-60.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: