Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 ± 2.40 to 14.21 ± 3.51 μM.
Keywords: Acylphloroglucinol meroterpenoid; Clusiaceae; Hypericum forrestii (Chittenden) N. Robson; Hyperiforins A-C; Protein tyrosine phosphatase 1B.
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