Synthetic biology approaches to actinomycete strain improvement

FEMS Microbiol Lett. 2021 Jun 11;368(10):fnab060. doi: 10.1093/femsle/fnab060.

Abstract

Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

Keywords: actinobacteria; actinomycete; biosynthesis; biotechnology; synthetic biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actinobacteria / genetics*
  • Actinobacteria / metabolism
  • Industrial Microbiology / methods
  • Industrial Microbiology / trends
  • Metabolic Engineering
  • Synthetic Biology / methods*
  • Synthetic Biology / trends