Role of long noncoding RNA taurine-upregulated gene 1 in cancers

Mol Med. 2021 May 26;27(1):51. doi: 10.1186/s10020-021-00312-4.

Abstract

Long non-coding RNAs (lncRNAs) are a group of non-protein coding RNAs with a length of more than 200 bp. The lncRNA taurine up-regulated gene 1 (TUG1) is abnormally expressed in many human malignant cancers, where it acts as a competitive endogenous RNA (ceRNA), regulating gene expression by specifically sponging its corresponding microRNAs. In the present review, we summarised the current understanding of the role of lncRNA TUG1 in cancer cell proliferation, metastasis, angiogenesis, chemotherapeutic drug resistance, radiosensitivity, cell regulation, and cell glycolysis, as well as highlighting its potential application as a clinical biomarker or therapeutic target for malignant cancer. This review provides the basis for new research directions for lncRNA TUG1 in cancer prevention, diagnosis, and treatment.

Keywords: Biomarker; Cancer; Competitive endogenous RNA (ceRNA); Long non-coding RNA (lncRNA); Taurine‐upregulated gene 1 (TUG1).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Biomarkers, Tumor*
  • Cell Cycle
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Disease Susceptibility
  • Gene Expression Regulation, Neoplastic* / drug effects
  • Humans
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism
  • RNA, Long Noncoding / genetics*
  • Signal Transduction

Substances

  • Biomarkers, Tumor
  • RNA, Long Noncoding
  • TUG1 long noncoding RNA, human