Histoplasmosis

Ana Belén Araúz; Padmasayee Papineni

doi:10.1016/j.idc.2021.03.011

Histoplasmosis

Infect Dis Clin North Am. 2021 Jun;35(2):471-491. doi: 10.1016/j.idc.2021.03.011.

Authors

Ana Belén Araúz¹, Padmasayee Papineni²

Affiliations

¹ Department of Infectious Diseases, Pasteur Suite, Ealing Hospital, London North West University Healthcare NHS Trust, Uxbridge Road, London, UB1 3HW, UK; Infectious Diseases Department, Hospital Santo Tomas, Avenida Balboa, Panama City, Panama.
² Infectious Diseases Department, Hospital Santo Tomas, Avenida Balboa, Panama City, Panama. Electronic address: p.papineni1@nhs.net.

PMID: 34016287
DOI: 10.1016/j.idc.2021.03.011

Abstract

Histoplasmosis is one of the commonest endemic mycoses in the Americas yet is often underdiagnosed and neglected as a public health priority. This review outlines the evolving understanding of its epidemiology and the clinical syndromes of histoplasmosis, in addition to up-to-date diagnostic and treatment guidelines. A focus on histoplasmosis in advanced HIV is included. The challenges pertinent to histoplasmosis management in Latin America, with recommendations made through international expert consensus are discussed.

Keywords: Antigen; Disseminated; HIV; Histoplasma; Histoplasmosis; Pulmonary; Serology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Endemic Diseases*
HIV Infections / complications*
Histoplasma / isolation & purification
Histoplasma / pathogenicity*
Histoplasmosis* / diagnosis
Histoplasmosis* / drug therapy
Histoplasmosis* / epidemiology
Humans
Immunocompromised Host