Ann Clin Biochem. 1988 May;25 ( Pt 3):233-6.

Urinary excretion of HMMA and HVA in infants.

Dale G, McGill AC, Seviour JA, Craft AW.

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Department of Clinical Biochemistry, Newcastle General Hospital, Newcastle upon Tyne, UK.

Abstract

Gas chromatography with flame ionisation detection has been used to establish the normal urinary excretion values of homovanillic acid and 4-hydroxy-3-methoxymandelic acid in 808 infants aged 6 months. This study, the essential pre-requisite for population screening for neuroblastoma in babies, reveals a mean homovanillic acid of 10.9 mumol/mmol creatinine and mean 4-hydroxy-3-methoxymandelic of 6.8 mumol/mmol creatinine. The upper 95% confidence interval were 25.5 mumol/mmol creatinine for homovanillic acid and 15.0 mumol/mmol creatinine for 4-hydroxy-3-methoxymandelic. Gas chromatography/mass spectrometry analysis of the 39 samples, (4.8%) with apparent increased excretion of one or both metabolites, revealed that this was, in each case, due to interfering peaks on chromatography.

PMID:: 3400977; [PubMed - indexed for MEDLINE]

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Urinary excretion of HMMA and HVA in infants.

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