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Am J Hum Genet. 1988 Aug;43(2):119-25.

A genetical model for vitiligo.

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  • 1Department of Biostatistics, University of Pittsburgh, PA 15261.

Abstract

A genetical model is found to provide a good fit to family data on vitiligo. The model postulates that recessive alleles at a set of four unlinked diallelic loci are involved in the causation of the disorder. Under this multiple recessive homozygosis model, for normal X affected families ascertained through the affected parent, the expected segregation probability is .063; the estimated value is 0.53, which is not significantly different from the expected value. For normal X normal families ascertained through an affected offspring, the expected segregation probability is .037; the estimated value is .04.

PMID:
3400640
[PubMed - indexed for MEDLINE]
PMCID:
PMC1715367
Free PMC Article
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