Prog Clin Biol Res. 1988;272:263-71.

Systemic meningococcal disease: a model infection to study acute endotoxinemia in man.

Brandtzaeg P, Kierulf P, Gaustad P, Dobloug J, Mollnes TE, Sirnes K.

Source

Department of Infectious Diseases, Ullevål University Hospital, Oslo, Norway.

Abstract

Plasma LPS were quantitated in 40 patients with bacteriological verified systemic meningococcal infection (SMD). Twenty-two patients (55%) demonstrated LPS greater than 25 pg/ml. Fourteen patients with initial plasma LPS levels greater than 700 pg/ml developed a severe septic shock, impaired renal function and extensive coagulopathy compared to 2 out of 26 patients with LPS levels below 700 pg/ml. Seven patients died due to the circulatory collapse and multiple organ failure all with initial LPS levels greater than 1,000 pg/ml. Initiation of antibiotic therapy did not result in further increase of plasma LPS concentration. LPS were cleared from the circulation with a half-life of 1.5-3 hours after initiation of antibiotic treatment with penicillin and chloramphenicol. The results suggest that plasma LPS are quantitatively related to the development of septic shock, multiple organ failure and death from these complications in SMD, making LPS measurement a direct prognostic marker.

PMID:: 3393567; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Medical

Meningococcal Infections - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease. [J Infect Dis. 1989]
Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease.
Brandtzaeg P, Kierulf P, Gaustad P, Skulberg A, Bruun JN, Halvorsen S, Sørensen E. J Infect Dis. 1989 Feb; 159(2):195-204.
The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide A in systemic meningococcal disease. [Thromb Res. 1989]
The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide A in systemic meningococcal disease.
Brandtzaeg P, Sandset PM, Joø GB, Ovstebø R, Abildgaard U, Kierulf P. Thromb Res. 1989 Aug 15; 55(4):459-70.
Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes. [J Exp Med. 1996]
Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes.
Brandtzaeg P, Osnes L, Ovstebø R, Joø GB, Westvik AB, Kierulf P. J Exp Med. 1996 Jul 1; 184(1):51-60.
Review Neisseria meningitidis lipopolysaccharides in human pathology. [J Endotoxin Res. 2001]
Review Neisseria meningitidis lipopolysaccharides in human pathology.
Brandtzaeg P, Bjerre A, Øvstebø R, Brusletto B, Joø GB, Kierulf P. J Endotoxin Res. 2001; 7(6):401-20.
Review [Studying the levels of endotoxemia in meningococcal sepsis. Its relations to pregnancy and antibiotic treatment]. [An Esp Pediatr. 1991]
Review [Studying the levels of endotoxemia in meningococcal sepsis. Its relations to pregnancy and antibiotic treatment].
Loscertales Abril M, Ruiz Extremera A, Rodríguez Contreras R, Galvez Vargas R, Gómez Vida J, Ibarra de la Rosa I, del Castillo Aguas G, Molina Font JA. An Esp Pediatr. 1991 May; 34(5):355-9.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Animal models of sepsis and sepsis-induced kidney injury. [J Clin Invest. 2009]
Review Animal models of sepsis and sepsis-induced kidney injury.
Doi K, Leelahavanichkul A, Yuen PS, Star RA. J Clin Invest. 2009 Oct; 119(10):2868-78. Epub 2009 Oct 1.
Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study. [BMJ. 2006]
Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study.
Harnden A, Ninis N, Thompson M, Perera R, Levin M, Mant D, Mayon-White R. BMJ. 2006 Jun 3; 332(7553):1295-8. Epub 2006 Mar 22.
Endotoxin induced cochlear damage. [Arch Dis Child. 1991]
Endotoxin induced cochlear damage.
Thomson A, Marzouk O. Arch Dis Child. 1991 Jul; 66(7):907-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Systemic meningococcal disease: a model infection to study acute endotoxinemia i...
Systemic meningococcal disease: a model infection to study acute endotoxinemia in man.
Prog Clin Biol Res. 1988 ;272:263-71.

PubMed
A comparison of the effectiveness of cysteamine and phosphocysteamine in elevati...
A comparison of the effectiveness of cysteamine and phosphocysteamine in elevating plasma cysteamine concentration and decreasing leukocyte free cystine in nephropathic cystinosis.
Pediatr Res. 1988 Jun ;23(6):616-20.

PubMed
The MOS short-form general health survey. Reliability and validity in a patient ...
The MOS short-form general health survey. Reliability and validity in a patient population.
Med Care. 1988 Jul ;26(7):724-35.

PubMed
A meta-analysis of alcohol consumption in relation to risk of breast cancer.
A meta-analysis of alcohol consumption in relation to risk of breast cancer.
JAMA. 1988 Aug 5 ;260(5):652-6.

PubMed
Anomalous pulmonary venous drainage of right lung to inferior vena cava ("scimit...
Anomalous pulmonary venous drainage of right lung to inferior vena cava ("scimitar syndrome"): clinical spectrum in older patients and role of surgery.
Q J Med. 1977 Oct ;46(184):463-83.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: