Quantitative evaluation of microvacuole formation in five intraocular lens models made of different hydrophobic materials

PLoS One. 2021 Apr 30;16(4):e0250860. doi: 10.1371/journal.pone.0250860. eCollection 2021.

Abstract

In this laboratory study, we assessed the resistance to microvacuole (glistening) formation in hydrophobic intraocular lenses (IOLs). Glistenings were induced in five lenses each of five different hydrophobic acrylic IOL models, using an established in vitro laboratory model: 800C (Rayner, Worthing, UK), AcrySof SN60WF (Alcon, Fort Worth, USA), Tecnis ZCB00 (Johnson & Johnson Vision, Santa Ana, USA), Vivinex XY1 (Hoya, Tokyo, Japan) and CT Lucia 611P (Zeiss, Oberkochen, Germany). We evaluated the number of microvacuoles per square millimeter (MV/mm2) in the central part of each IOL. Results were analyzed statistically, and mean glistening numbers were ranked, with the highest in the SN60WF which had 66.0 (±45.5) MVs/mm, followed by the 611P with 30.7 (±8.4) MVs/mm2. The 800C and XY1 showed comparable values of 2.0 (±3.6) and 2.7 (±2.4) MVs/mm2, respectively. ZCB00 had the lowest number with 0.9 (±0.6) MVs/mm2. This study shows that the resistance to glistening formation differs depending on the hydrophobic acrylic copolymer composition of the IOL material. Some IOLs from current clinical use are still prone to develop glistenings whereas others, including the ZCB00, 800C and XY1 show high resistance to microvacuole formation.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • In Vitro Techniques
  • Lenses, Intraocular*
  • Polymers / chemistry*
  • Stress, Mechanical
  • Temperature

Substances

  • Acrylic Resins
  • Polymers

Grants and funding

T. Yildirim was funded by the Physician-Scientist Program of the Heidelberg University, Faculty of Medicine. Q. Wang was funded by the China Scholarship Council of the Chinese Ministry of Education. G. Auffarth receives funding from the Klaus Tschira Stiftung, Heidelberg, Germany. The funding organizations had no specific role in this research.