Abstract
Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules.
Keywords:
NLRP3 inhibitors; auto-active inflammasomes; inflammasomes; small molecules; techniques to assay inflammasome activation.
MeSH terms
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Alarmins / immunology
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Alarmins / metabolism
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Computer Simulation
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Cytokines / metabolism
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Drug Design
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Humans
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Immunity, Innate
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Immunologic Techniques
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Inflammasomes / drug effects*
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Inflammasomes / immunology
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Inflammasomes / metabolism
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Inflammation / drug therapy
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Inflammation / immunology
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Inflammation / metabolism
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Intracellular Signaling Peptides and Proteins / immunology
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Intracellular Signaling Peptides and Proteins / metabolism
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Models, Biological
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Pathogen-Associated Molecular Pattern Molecules / immunology
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Pathogen-Associated Molecular Pattern Molecules / metabolism
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Small Molecule Libraries
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Structure-Activity Relationship
Substances
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Alarmins
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Anti-Inflammatory Agents
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Cytokines
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Inflammasomes
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Intracellular Signaling Peptides and Proteins
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Pathogen-Associated Molecular Pattern Molecules
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Small Molecule Libraries