J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):582-5.

Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.

Noda S, Umezaki H, Yamamoto K, Araki T, Murakami T, Ishii N.

Source

Department of Neurology, Kyushukoseinenkin Hospital, Kitakyushu, Japan.

Abstract

Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.

PMID:: 3379435; [PubMed - indexed for MEDLINE]
PMCID: PMC1032980

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Chemical compound information

pantogab

MW: 233.26 g/mol

MF: C₁₀H₁₉NO₅

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Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.

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