An indispensable tool: Exosomes play a role in therapy for radiation damage

Sijia Li; Lihong Shao; Tiankai Xu; Xin Jiang; Guozi Yang; Lihua Dong

doi:10.1016/j.biopha.2021.111401

An indispensable tool: Exosomes play a role in therapy for radiation damage

Biomed Pharmacother. 2021 May:137:111401. doi: 10.1016/j.biopha.2021.111401. Epub 2021 Mar 2.

Authors

Sijia Li¹, Lihong Shao², Tiankai Xu³, Xin Jiang⁴, Guozi Yang⁵, Lihua Dong⁶

Affiliations

¹ Department of Radiation Oncology and Therapy, Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University, Jilin, Changchun, 130000, China. Electronic address: lisj0414@163.com.
² Department of Radiation Oncology and Therapy, Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University, Jilin, Changchun, 130000, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: 326730262@qq.com.
³ Department of Radiation Oncology and Therapy, Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University, Jilin, Changchun, 130000, China. Electronic address: tiankxu@gmail.com.
⁴ Department of Radiation Oncology and Therapy, Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University, Jilin, Changchun, 130000, China. Electronic address: jiangx@jlu.edu.cn.
⁵ Department of Radiation Oncology and Therapy, Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University, Jilin, Changchun, 130000, China. Electronic address: ygz@jlu.edu.cn.
⁶ Department of Radiation Oncology and Therapy, Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University, Jilin, Changchun, 130000, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: dlh@jlu.edu.cn.

PMID: 33761615
DOI: 10.1016/j.biopha.2021.111401

Abstract

Radiotherapy is one of the three main treatments for tumors. Almost 70% of tumor patients undergo radiotherapy at different periods. Although radiotherapy can enhance the local control rate of tumors and patients' quality of life, normal tissues often show radiation damage following radiotherapy. In recent years, several studies have shown that exosomes could be biomarkers for diseases and be involved in the treatment of radiation damage. Exosomes are nanoscale vesicles containing complex miRNAs and proteins. They can regulate the inflammatory response, enhance the regeneration effect of damaged tissue, and promote the repair of damaged tissues and cells, extending their survival time. In addition, their functions are achieved by paracrine signaling. In this review, we discuss the potential of exosomes as biomarkers and introduce the impact of exosomes on radiation damage in different organs and the hematopoietic system in detail.

Keywords: Biomarker; Exosome; Radiation damage; Radiotherapy; Therapy; Tumor.

Publication types

Review

MeSH terms

Animals
Biomarkers
Exosomes / physiology*
Exosomes / radiation effects*
Humans
Quality of Life
Radiation Injuries / diagnosis
Radiation Injuries / therapy*
Radiation Injuries, Experimental / diagnosis
Radiation Injuries, Experimental / therapy*
Radiotherapy / adverse effects

Substances

Biomarkers