Proc Natl Acad Sci U S A. 1977 Nov;74(11):5091-5.

Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast.

Abstract

A diploid strain of yeast (Saccharomyces cerevisiae) was found to be heterozygous for two forms of the highly repetitious ribosomal DNA. These forms could be distinguished by the pattern of fragments produced after digestion with the site-specific restriction endonuclease EcoRI. The mode of inheritance of ribosomal DNA was determined by tetrad analysis. Of 14 tetrads analyzed, 12 clearly showed the ribosomal DNA forms segregating as a single Mendelian unit. The simplest interpretation of this result is that all of the approximately 100 copies of the ribosomal DNA genes of the yeast cell are located on one chromosome and that meiotic recombination within these genes is suppressed. Two of the 14 tetrads showed the segregation patterns expected as the result of mitotic recombination within the ribosomal DNA.

PMID:: 337310; [PubMed - indexed for MEDLINE]
PMCID:: PMC432105

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae. [Mol Cell Biol. 1984]
Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae.
Horowitz H, Thorburn P, Haber JE. Mol Cell Biol. 1984 Nov; 4(11):2509-17.
Meiotic mapping of yeast ribosomal deoxyribonucleic acid on chromosome XII. [J Bacteriol. 1979]
Meiotic mapping of yeast ribosomal deoxyribonucleic acid on chromosome XII.
Petes TD. J Bacteriol. 1979 Apr; 138(1):185-92.
3 micron DNA - an extrachromosomal ribosomal DNA in the yeast Saccharomyces cerevisiae. [Gene. 1980]
3 micron DNA - an extrachromosomal ribosomal DNA in the yeast Saccharomyces cerevisiae.
Larionov VL, Grishin AV, Smirnov MN. Gene. 1980 Dec; 12(1-2):41-9.
Simple Mendelian inheritance of the repeating yeast ribosomal DNA genes. [Cold Spring Harb Symp Quant Bi...]
Simple Mendelian inheritance of the repeating yeast ribosomal DNA genes.
Petes TD, Hereford LM, Botstein D. Cold Spring Harb Symp Quant Biol. 1978; 42 Pt 2:1201-7.
Review [Genetic control of mitotic recombination in Saccharomyces cerevisiae yeast]. [Genetika. 1993]
Review [Genetic control of mitotic recombination in Saccharomyces cerevisiae yeast].
Korolev VG. Genetika. 1993 Feb; 29(2):197-211.

See reviews... See all...

Cited by 55 PubMed Central articles

A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. [Cell. 2011]
A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation.
Pan J, Sasaki M, Kniewel R, Murakami H, Blitzblau HG, Tischfield SE, Zhu X, Neale MJ, Jasin M, Socci ND, et al. Cell. 2011 Mar 4; 144(5):719-31.
Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe. [Eukaryot Cell. 2010]
Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.
Motwani T, Doris R, Holmes SG, Flory MR. Eukaryot Cell. 2010 Oct; 9(10):1612-21. Epub 2010 Aug 13.
Switching from prokaryotic molecular biology to eukaryotic molecular biology. [J Biol Chem. 2009]
Switching from prokaryotic molecular biology to eukaryotic molecular biology.
Nomura M. J Biol Chem. 2009 Apr 10; 284(15):9625-35. Epub 2008 Dec 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast.
Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast.
Proc Natl Acad Sci U S A. 1977 Nov ;74(11):5091-5.

PubMed
Genetic expression of amyloid and glial-specific protein in the Alzheimer brain.
Genetic expression of amyloid and glial-specific protein in the Alzheimer brain.
J Am Geriatr Soc. 1988 Jun ;36(6):558-64.

PubMed
The effect of head-induced interaural time and level differences on speech intel...
The effect of head-induced interaural time and level differences on speech intelligibility in noise.
J Acoust Soc Am. 1988 Apr ;83(4):1508-16.

PubMed
Posterior interosseous nerve palsy in rheumatoid arthritis.
Posterior interosseous nerve palsy in rheumatoid arthritis.
J Bone Joint Surg Br. 1988 May ;70(3):468-71.

PubMed
Gene expression of rat and human microsomal glutathione S-transferases.
Gene expression of rat and human microsomal glutathione S-transferases.
J Biol Chem. 1988 Jun 15 ;263(17):8430-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: