Recent advances in understanding assembly of the primary cilium membrane

Saurabh Shakya; Christopher J Westlake

doi:10.12703/r/10-16

Recent advances in understanding assembly of the primary cilium membrane

Fac Rev. 2021 Feb 22:10:16. doi: 10.12703/r/10-16. eCollection 2021.

Authors

Saurabh Shakya¹, Christopher J Westlake¹

Affiliation

¹ Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Laboratory of Cellular and Developmental Signaling, Frederick, MD 21702, USA.

Abstract

Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins have been linked to ciliogenesis, which proceeds through a highly coordinated multistage process at the distal end of centrioles requiring membranes. In this short review, we focus on recently reported insights into the biogenesis of the primary cilium membrane and its association with other ciliogenic processes in the intracellular ciliogenesis pathway.

Keywords: Ciliogenesis; Rab; ciliopathy; membrane trafficking; primary cilium.

Publication types

Review

Grants and funding

SS and CJW are supported by federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.