Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

Giuseppe Limongelli; Emanuele Monda; Antonello D'Aponte; Martina Caiazza; Marta Rubino; Augusto Esposito; Giuseppe Palmiero; Elisabetta Moscarella; Giovanni Messina; Paolo Calabro'; Olga Scudiero; Giuseppe Pacileo; Marcellino Monda; Eduardo Bossone; Sharlene M Day; Iacopo Olivotto

doi:10.1016/j.hfc.2021.01.003

Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

Heart Fail Clin. 2021 Apr;17(2):303-313. doi: 10.1016/j.hfc.2021.01.003. Epub 2021 Feb 10.

Authors

Giuseppe Limongelli¹, Emanuele Monda², Antonello D'Aponte³, Martina Caiazza², Marta Rubino², Augusto Esposito², Giuseppe Palmiero², Elisabetta Moscarella², Giovanni Messina³, Paolo Calabro'², Olga Scudiero⁴, Giuseppe Pacileo², Marcellino Monda³, Eduardo Bossone⁵, Sharlene M Day⁶, Iacopo Olivotto⁷

Affiliations

¹ Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Via L. Bianchi, 80131 Naples, Italy; Institute of Cardiovascular Sciences, University College of London and St. Bartholomew's Hospital, Grower Street, London WC1E 6DD, UK. Electronic address: limongelligiuseppe@libero.it.
² Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Via L. Bianchi, 80131 Naples, Italy.
³ Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli, 80138 Naples, Italy.
⁴ Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via G. Salvatore, 80138 Naples, Italy; CEINGE Advanced Biotechnologies, Via G. Salvatore, 80138 Naples, Italy; Task Force on Microbiome Studies, University of Naples "Federico II", Via G. Salvatore, 80138 Naples, Italy.
⁵ Division of Cardiology, Antonio Cardarelli Hospital, Via A. Cardarelli, 80131 Naples, Italy.
⁶ Department of Internal Medicine, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA.
⁷ Cardiomyopathy Unit and Genetic Unit, Careggi University Hospital, Largo Brambrilla, 50134 Florence, Italy.

PMID: 33673954
DOI: 10.1016/j.hfc.2021.01.003

Abstract

We evaluated the impact of weight loss (WL) using a Mediterranean diet and mild-to-moderate-intensity aerobic exercise program, on clinical status of obese, symptomatic patients with hypertrophic cardiomyopathy (HCM). Compared with nonresponders, responders showed a significant reduction of left atrial diameter, left atrial volume index (LAVI), E/E'average, pulmonary artery systolic pressure (PASP), and a significant increase in Vo_2max (%) and peak workload. Body mass index changes correlated with reduction in left atrial diameter, LAVI, E/E'average, PASP, and increase of Vo_2max (mL/Kg/min), Vo_2max (%), peak workload. Mediterranean diet and aerobic exercise is associated with clinical-hemodynamic improvement in obese symptomatic HCM patients.

Keywords: Aerobic exercise; Hypertrophic cardiomyopathy; Mediterranean diet; Obesity.

Publication types

Review

MeSH terms

Cardiomyopathy, Hypertrophic / epidemiology
Cardiomyopathy, Hypertrophic / physiopathology
Cardiomyopathy, Hypertrophic / therapy*
Comorbidity
Diet, Mediterranean*
Exercise / physiology*
Exercise Test
Humans
Obesity / epidemiology*
Weight Loss / physiology*