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Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia.
The toxic effects of oral diphenhydramine are well documented and include central nervous system and anticholinergic symptomatology. We present a case of diphenhydramine intoxication from combined oral/percutaneous medication. Overzealous application of a commercially available topical diphenhydramine preparation resulted in hallucinations and other side effects in a five-year-old child with varicella.
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