GluD to the edge: synaptic organizer competition shapes dendrite arbors

Hong Lu; Ann Marie Craig

doi:10.1016/j.neuron.2021.01.019

GluD to the edge: synaptic organizer competition shapes dendrite arbors

Neuron. 2021 Feb 17;109(4):566-568. doi: 10.1016/j.neuron.2021.01.019.

Authors

Hong Lu¹, Ann Marie Craig²

Affiliations

¹ Djavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, BC, V6T 2B5, Canada.
² Djavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, BC, V6T 2B5, Canada. Electronic address: acraig@mail.ubc.ca.

PMID: 33600752
DOI: 10.1016/j.neuron.2021.01.019

Abstract

The relationship between synaptogenesis and dendritogenesis is poorly understood, particularly in mammals. In this issue of Neuron, Takeo et al. (2021) manipulate synaptic organizers GluD2 and cerebellin-1 to show that Purkinje cells regulate how their dendrites branch by competing with neighboring cells for synaptic real estate.

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MeSH terms

Animals
Dendrites
Neurogenesis
Neurons*
Purkinje Cells*