Abstract
In this work, we have developed a simple and reliable platform for simultaneous analysis of telomerase and miRNA. A three-dimensional bipedal DNA walking strategy is designed utilizing gold nanoparticles and MnO2 nanosheets. Given the merits of fast, sensitive and selective analysis, the developed method has great potential application in early clinical diagnosis.
MeSH terms
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DNA Probes / chemistry
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DNA Probes / genetics
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DNA, Catalytic / chemistry*
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DNA, Catalytic / genetics
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Gold / chemistry
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HeLa Cells
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Humans
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Immobilized Nucleic Acids / chemistry
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Immobilized Nucleic Acids / genetics
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Logic*
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Manganese Compounds / chemistry
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Metal Nanoparticles / chemistry
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MicroRNAs / analysis*
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MicroRNAs / genetics
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Microscopy, Confocal
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Microscopy, Fluorescence
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Nucleic Acid Conformation
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Nucleic Acid Hybridization
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Oxides / chemistry
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Spectrometry, Fluorescence / methods*
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Telomerase / analysis*
Substances
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DNA Probes
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DNA, Catalytic
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Immobilized Nucleic Acids
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Manganese Compounds
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MicroRNAs
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Oxides
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Gold
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Telomerase
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manganese dioxide