Hepatic Scavenger Receptor Class B Type 1 Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1474-1486. doi: 10.1161/ATVBAHA.121.315882. Epub 2021 Feb 11.

Abstract

[Figure: see text].

Keywords: atherosclerosis; brown adipose tissue; cardiovascular diseases; lipoprotein; triglyceride.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, Brown / drug effects
  • Adipose Tissue, Brown / metabolism*
  • Adrenergic beta-3 Receptor Agonists / pharmacology*
  • Animals
  • Apolipoprotein E3 / genetics
  • Apolipoprotein E3 / metabolism*
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism
  • Atherosclerosis / pathology
  • Atherosclerosis / prevention & control*
  • Biomarkers / blood
  • Cholesterol Ester Transfer Proteins / genetics
  • Cholesterol Ester Transfer Proteins / metabolism*
  • Dioxoles / pharmacology*
  • Disease Models, Animal
  • Gene Knockdown Techniques*
  • Humans
  • Lipids / blood*
  • Lipolysis / drug effects
  • Liver / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Plaque, Atherosclerotic
  • RNA Interference
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Scavenger Receptors, Class B / deficiency*
  • Scavenger Receptors, Class B / genetics

Substances

  • Adrenergic beta-3 Receptor Agonists
  • Apolipoprotein E3
  • Biomarkers
  • CETP protein, human
  • Cholesterol Ester Transfer Proteins
  • Dioxoles
  • Lipids
  • RNA, Small Interfering
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B
  • disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate