Interstitial lung disease and obstructive sleep apnea

Yet H Khor; Christopher J Ryerson; Shane A Landry; Mark E Howard; Thomas J Churchward; Bradley A Edwards; Garun S Hamilton; Simon A Joosten

doi:10.1016/j.smrv.2021.101442

Interstitial lung disease and obstructive sleep apnea

Sleep Med Rev. 2021 Aug:58:101442. doi: 10.1016/j.smrv.2021.101442. Epub 2021 Jan 22.

Authors

Yet H Khor¹, Christopher J Ryerson², Shane A Landry³, Mark E Howard⁴, Thomas J Churchward⁵, Bradley A Edwards³, Garun S Hamilton⁶, Simon A Joosten⁷

Affiliations

¹ Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia; Institute for Breathing and Sleep, Heidelberg, Victoria, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
² Centre for Heart Lung Innovation, Providence Health Care, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
³ Sleep and Circadian Medicine Laboratory, Department of Physiology, Monash University, Victoria, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Australia.
⁴ Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia; Institute for Breathing and Sleep, Heidelberg, Victoria, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Australia.
⁵ Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia; Institute for Breathing and Sleep, Heidelberg, Victoria, Australia.
⁶ Monash Lung and Sleep, Victoria, Australia; School of Clinical Sciences, Monash University, Victoria, Australia.
⁷ Monash Lung and Sleep, Victoria, Australia; School of Clinical Sciences, Monash University, Victoria, Australia. Electronic address: drjoosten@hotmail.com.

PMID: 33561604
DOI: 10.1016/j.smrv.2021.101442

Abstract

Obstructive sleep apnea (OSA) is one of the most common comorbidities in patients with interstitial lung disease (ILD). Growing evidence highlights the significance of sleep disturbance on health outcomes in this population. The relationships between ILD and OSA are complex and possibly bidirectional, with multiple mechanisms postulated for the pathogenic and physiologic links. This review synthesizes current evidence and hypotheses regarding different aspects of the relationships between ILD and OSA, emphasizing the interactions between epidemiology, pathogenesis, and pathophysiology.

Keywords: Interstitial lung disease; Obstructive sleep apnea; Pulmonary fibrosis; Sleep.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Comorbidity
Humans
Lung Diseases, Interstitial* / epidemiology
Sleep Apnea, Obstructive* / epidemiology
Sleep Wake Disorders*