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J Biol Chem. 1988 Apr 5;263(10):4520-2.

A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor.

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  • 1Central Research and Development Department, E. I. du Pont de Nemours and Company, Inc., Wilmington, Delaware 19898.

Erratum in

  • J Biol Chem 1988 Jul 15;263(20):10040.


An interferon-induced 15-kDa protein is synthesized from a precursor of higher molecular weight; the precursor contains 165 amino acids (17 kDa), whereas the stable product (15 kDa) contains 156 amino acids. The stable 15-kDa form is derived from the precursor 17-kDa form by the removal of eight amino acids from the COOH terminus and the methionine from the NH2 terminus. The existence of the precursor 17-kDa protein can be demonstrated after brief periods of in vivo labeling with [35S]methionine and by translation of mRNA in vitro.

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