A Zinc Finger Transcription Factor Faithfully Dedicated to Only a Single Target Gene in Erythroid Cells

Juhyun Kim; Ann Dean

doi:10.1016/j.molcel.2020.12.023

A Zinc Finger Transcription Factor Faithfully Dedicated to Only a Single Target Gene in Erythroid Cells

Mol Cell. 2021 Jan 21;81(2):218-219. doi: 10.1016/j.molcel.2020.12.023.

Authors

Juhyun Kim¹, Ann Dean²

Affiliations

¹ Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: annd@niddk.nih.gov.

PMID: 33482089
DOI: 10.1016/j.molcel.2020.12.023

Abstract

Lan et al. carry out a CRISPR-mediated genetic screen and discover that ZNF410 uniquely regulates the NuRD component CHD4 to repress γ-globin transcription in erythroid cells, establishing a novel fetal hemoglobin regulatory mechanism.

Published by Elsevier Inc.

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MeSH terms

Erythroid Cells
Fetal Hemoglobin* / genetics
Transcription Factors* / genetics
Zinc Fingers / genetics
gamma-Globins

Substances

Transcription Factors
gamma-Globins
Fetal Hemoglobin