Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

Phys Imaging Radiat Oncol. 2019 Nov 20:12:17-21. doi: 10.1016/j.phro.2019.10.004. eCollection 2019 Oct.

Abstract

The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV), the Microdosimetric Kinetic Model (MKM) and the NanOx model for HSG, V79 and CHO-K1 cells in response to monoenergetic irradiations. Although the LEM IV and the MKM predictions accurately reproduced the trend observed in the data, NanOx yielded a better agreement than the other models for more irradiation configurations. Its χ 2 estimator was indeed the lowest for three over seven considered cases.

Keywords: Benchmark; Biophysical modeling; Hadrontherapy; Monoenergetic ions.