FEBS Lett. 1988 Feb 8;228(1):123-7.

Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain.

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Laboratory of Developmental Chronobiology, Children's Service, Massachusetts General Hospital, Boston 02114.

Abstract

Iodinated melatonin was used to study melatonin sites of action in brain. Iodomelatonin mimicked the effects of melatonin on reproductive development in Djungarian hamster fetuses. 125I-melatonin injected into the dam was recovered from fetal brain. In vitro autoradiographic studies revealed a remarkably discrete distribution of competitive 125I-melatonin-binding sites in the fetal brain, with binding in median eminence/arcuate nucleus area greater than suprachiasmatic nucleus greater than pineal gland much greater than anterior pituitary gland much greater than preoptic area. 125I-melatonin promises to be a useful tool for understanding the sites and mechanism of action of melatonin.

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Characteristics and autoradiographic localization of 2-[125I]iodomelatonin binding sites in Djungarian hamster brain. [Endocrinology. 1989]
Characteristics and autoradiographic localization of 2-[125I]iodomelatonin binding sites in Djungarian hamster brain.
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Cited by 2 PubMed Central articles

Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain. [Proc Natl Acad Sci U S A. 1989]
Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain.
Rivkees SA, Carlson LL, Reppert SM. Proc Natl Acad Sci U S A. 1989 May; 86(10):3882-6.
D1-dopamine receptors activate c-fos expression in the fetal suprachiasmatic nuclei. [Proc Natl Acad Sci U S A. 1992]
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Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain.

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