RETRACTED: microRNA-139-5p alleviates neurological deficit in hypoxic-ischemic brain damage via HDAC4 depletion and BCL-2 activation

Brain Res Bull. 2021 Apr:169:73-80. doi: 10.1016/j.brainresbull.2020.12.020. Epub 2021 Jan 2.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief as there are concerns about the reliability of the results. Concerns have been raised about the western blot bands in Figs. 5A, 6D having the same eyebrow shaped phenotype as found in many other publications as tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0). The journal requested the corresponding author to comment on these concerns and send the raw data, however the author was not able to provide uncropped images of the original gels. The Editor-in-Chief therefore no longer has confidence in the data and conclusions of this study.

Keywords: Bcl-2; Development; HDAC4; Hypoxic-ischemic brain damage; Neural behavior; microRNA-139-5p.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Brain / metabolism*
  • Disease Models, Animal
  • Histone Deacetylases / genetics
  • Histone Deacetylases / metabolism*
  • Hypoxia-Ischemia, Brain / genetics
  • Hypoxia-Ischemia, Brain / metabolism*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Neurons / metabolism
  • Oxidative Stress / physiology
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Up-Regulation

Substances

  • Bcl2 protein, rat
  • MicroRNAs
  • Proto-Oncogene Proteins c-bcl-2
  • HDAC4 protein, rat
  • Histone Deacetylases