Human hTM alpha gene: expression in muscle and nonmuscle tissue

Mol Cell Biol. 1988 Jan;8(1):433-40. doi: 10.1128/mcb.8.1.433-440.1988.

Abstract

We have isolated a cDNA clone from a human skeletal muscle library which contains the complete protein-coding sequence of a skeletal muscle alpha-tropomyosin. This cDNA sequence defines a fourth human tropomyosin gene, the hTM alpha gene, which is distinct from the hTMnm gene encoding a closely related isoform of skeletal muscle alpha-tropomyosin. In cultured human fibroblasts, the hTM alpha gene encodes both skeletal-muscle- and smooth-muscle-type alpha-tropomyosins by using an alternative mRNA-splicing mechanism.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • Fibroblasts / physiology
  • Gene Expression Regulation
  • Genes
  • Humans
  • Molecular Sequence Data
  • Muscles / physiology*
  • RNA Splicing
  • RNA, Messenger / genetics
  • Tissue Distribution
  • Tropomyosin / genetics*

Substances

  • RNA, Messenger
  • Tropomyosin

Associated data

  • GENBANK/M19713
  • GENBANK/M19714
  • GENBANK/M19715