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J Pediatr Orthop. 1988 Jan-Feb;8(1):71-2.

Is APD a promising drug in the treatment of severe osteogenesis imperfecta?

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  • 1Service de Rhumatologie, Cliniques Universitaires U.C.L. de Mont-Godinne et St-Luc, Bruxelles, Belgique.


The efficacy of (3-amino-1-hydroxypropylidene)-1,1-biphosphonate (APD) is reported in a severe case of osteogenesis imperfecta (OI). An increased density at the metaphysis level is demonstrated on wrist radiograph. Similar findings have been observed in two other children with OI at various metaphyseal levels (e.g., tibia, femur). To our knowledge, this is the first time the effect of APD in children with severe OI has been reported.

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